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In the context of the Austrian Genome Program a tissue bank is being established (Genome Austria Tissue Bank, GATiB) which builds on a collection of diseased and corresponding normal tissues representing all diseases at the natural frequency of occurrence from a non-selected central European population of more than 700.000 patients.
An IT-infrastructure is an essential component of a biobank. We will develop an innovative architecture to support the collection, administration, and retrieval of material and data about this material, support the scientists in performing studies, and support the management of scarce resources (material, machinery, and analytical resources). The major challenges for the IT-infrastructure are: 
Partiality: the biobank is intended to be one node in a federation  of biobanks. It needs  the descriptive capabilities to be useful for other nodes in the network and it needs the capability to make use  of other biobanks. This needs careful design of metadata about the contents of the biobank, the acceptance  and interoperability of heterogeneous partner resources.
Longevity: the biobank is intended to be a long lasting research infrastructure which will be active for a long  period of time. Many changes will occur: new diagnostic codes, new therapies, new analytical methods, new  legal regulations, and new IT standards. The biobank needs to be ready to incorporate such changes and  make best use of the available data already collected in spite of such changes.
Confidentiality: The biobank stores or links to patient related data. Personal data and genomic data are  considered highly sensitive in many countries. The IT-infrastructure has to provide means to protect the  confidentiality of protected data on one side and has to allow for best possible use of data for studies  respecting confidentiality constraints.<style type="text/css">


R&D Projekte, öffentliche Finanzierung
2006 - 2009
Institut für Knowledge and Business Engineering
Fakultät für Informatik
Universität Wien

Währinger Straße 29
1090 Wien