In the context of the Austrian Genome Program a tissue bank is being established (Genome Austria Tissue Bank, GATiB) which builds on a collection of diseased and corresponding normal tissues representing all diseases at the natural frequency of occurrence from a non-selected central European population of more than 700.000 patients.
An IT-infrastructure is an essential component of a biobank. We will develop an innovative architecture to support the collection, administration, and retrieval of material and data about this material, support the scientists in performing studies, and support the management of scarce resources (material, machinery, and analytical resources). The major challenges for the IT-infrastructure are:
Partiality: the biobank is intended to be one node in a federation of biobanks. It needs the descriptive capabilities to be useful for other nodes in the network and it needs the capability to make use of other biobanks. This needs careful design of metadata about the contents of the biobank, the acceptance and interoperability of heterogeneous partner resources.
Longevity: the biobank is intended to be a long lasting research infrastructure which will be active for a long period of time. Many changes will occur: new diagnostic codes, new therapies, new analytical methods, new legal regulations, and new IT standards. The biobank needs to be ready to incorporate such changes and make best use of the available data already collected in spite of such changes.
Confidentiality: The biobank stores or links to patient related data. Personal data and genomic data are considered highly sensitive in many countries. The IT-infrastructure has to provide means to protect the confidentiality of protected data on one side and has to allow for best possible use of data for studies respecting confidentiality constraints.<style type="text/css">
- Research Lab Computational Technologies and Applications
- Institut für Knowledge and Business Engineering
- Forschungsgruppe Workflow Systems and Technology
|R&D Projekte, öffentliche Finanzierung|
|2006 - 2009|
|Institut für Knowledge and Business Engineering|